Acantholysis, resulting from desmosome weakening by autoantibodies directed against the protein desmoglein, is the disease mechanism attributed to which of the following?
Correct Answer: Pemphigus vulgaris
Description: In pemphigus vulgaris, autoantibodies attach to antigens (desmoglein) found in desmosomes that keep keratinocytes linked to each other. Cells eventually separate from each other (acantholysis), resulting in short-lived intraepithelial vesicles/bullae.
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Pathology
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